Lenisna PDLLA

Lenisna is an injectable hybrid product combining hyaluronic acid (HA) with PDLLA — Poly-D,L-Lactic acid — microparticles. The HA component delivers immediate hydration and a soft volumising effect at injection. The PDLLA microparticles act as a biostimulator: they are gradually metabolised over months and, during that process, signal fibroblasts to produce new collagen. The result is a dual effect — instant subtle change from the HA, plus a progressive, longer-lasting collagen-driven improvement in skin quality and structure that develops over 3–6 months and lasts up to about 2 years.

Yes — Lenisna is a CE-marked medical product available for use in licensed UK aesthetic practice. It should only be administered by a medically trained practitioner experienced in biostimulator injection technique. PDLLA-based biostimulators are technically more demanding than pure HA fillers and require correct placement depth, dilution, and post-treatment massage protocol to avoid nodule formation.

Both are PDLLA + HA hybrid products and both work through a similar dual mechanism (immediate HA volume + progressive PDLLA collagen stimulation). Practical differences come down to particle characteristics, gel consistency, and the carrier formulation — Lenisna and JuveLook are manufactured by different companies with slightly different rheology and recommended dilution protocols. The choice between them is made by your practitioner based on the treatment area, your skin's current condition, and the result you're seeking. At INNODERM both are available as part of the broader Skin Boosters offering.

The HA component fades over months (usually 3–6 months). The collagen-driven structural improvement triggered by the PDLLA outlasts the HA — most patients see results lasting 18–24 months from a completed course of treatment. Maintenance is then typically a single session every 12–18 months to preserve the collagen-stimulating effect. Individual longevity varies based on skin quality at baseline, age, lifestyle factors (sun, smoking), and the area treated.

Lenisna is most often used to improve skin QUALITY (texture, firmness, fine lines) rather than to add structural volume. Common areas: cheeks (for crepiness and dullness), neck (a notoriously hard-to-treat area), décolletage (sun damage and lines), and the lower face for skin firming without adding structural lift. It is not typically used as a structural cheekbone-builder or jaw-sculptor — those goals are better served by traditional cohesive HA fillers. Your practitioner will recommend the right tool during consultation.

A standard course is 2–3 sessions spaced 4 weeks apart. Maintenance is then typically once every 12–18 months. Some patients with more sun-damaged or more depleted skin benefit from 4 initial sessions. The collagen-driven effect builds across sessions — peak visible result is usually seen approximately 3 months after the final session.

PDLLA microparticles must be evenly distributed in the tissue immediately after injection to prevent local clumping. If clumps form before the body's repair response surrounds and integrates the particles, nodules can develop — small, sometimes-firm bumps under the skin that can persist for months. The standard rule is "5-5-5": massage 5 minutes, 5 times per day, for 5 days post-treatment. Your practitioner will demonstrate the technique and provide written aftercare. Skipping or shortening massage significantly increases nodule risk.

Yes — biostimulators and traditional injectables address different goals and combine well in a comprehensive plan. Lenisna works on skin quality and progressive collagen build. HA fillers (Juvederm, Restylane, Teosyal) deliver immediate structural volume. Anti-wrinkle injections relax dynamic muscle lines. A common multi-modality plan stages these treatments over weeks: HA fillers and/or anti-wrinkle injections first to address structural and dynamic concerns, then Lenisna added to improve overall skin quality. Combination plans are designed in consultation to avoid overloading the tissue.